circRNA basic information
circBase ID: hsa_circ_0007521
Name: hsa_circ_PTK2
Synonym: Circ PTK2 / circRNA PTK2
Host Gene: PTK2
Genomic location(hg19): chr8:141810557-141900868:-
Genomic location(hg38): chr8:140800458-140890769:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0013209
MONDO name: metabolic dysfunction-associated steatotic liver disease
Disease details: nonalcoholic fatty liver disease / NAFLD
Disease DO ID:
 0080208
Disease MeSH ID:
 D065626
Disease NCIt ID:
 C84444
Disease ICD11 ID:
 1912806631
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

liver tissue
Cell lines:

HepG2
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
DN
Associated gene: SIK2, PI3K, Akt, Ago2
Associated microRNA: miR-200c
Biological function: Inhibits hepatic lipid accumulation and suppresses NAFLD progression.
Molecular mechanism: circ PTK2 acts as a sponge for miR-200c, relieving repression of SIK2 and thereby inhibiting PI3K/Akt signaling.
Biological pathway or process:

PI3K/AKT (inhibits); lipid metabolism (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; Western Blot; Oil Red O Staining; IHC (Immunohistochemistry); H&E Staining; In Vivo Animal Model
Clinical significance:

-
Description:

circ PTK2 is down-regulated in NAFLD models. Its overexpression reduces hepatocyte lipid accumulation by sponging miR-200c, restoring SIK2 expression and inhibiting PI3K/Akt signaling, thereby alleviating NAFLD progression in vitro and in HFD-induced mice.
Confidence score:

0.6811
Other information
Title:

Overexpression of circ PTK2 suppresses the progression of nonalcoholic fatty liver disease via the miR-200c/SIK2/PI3K/Akt axis.

Journal: The Kaohsiung journal of medical sciences
Published: 2022
PubMed ID: 35791807
Study type:

biological research
Data availability: -
Code availability: -