| Expression pattern: |
UP |
| Associated gene: |
SLC7A11, PI3K, AKT |
| Associated microRNA: |
miR-557 |
| Biological function: |
promotes proliferation, migration and invasion; suppresses apoptosis; promotes xenograft tumor growth |
| Molecular mechanism: |
ceRNA mechanism: circEIF6 sponges miR-557 to upregulate SLC7A11 and activate PI3K/AKT signaling |
| Biological pathway or process: |
PI3K/AKT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; In Vivo Animal Model; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
circEIF6 expression was positively related to TNM stage and showed diagnostic value (ROC AUC=0.9093). |
| Description: |
circEIF6 (hsa_circ_0060055) is up-regulated in pancreatic cancer and promotes malignant phenotypes and xenograft growth. Mechanistically, it sponges miR-557 to relieve repression of SLC7A11 and thereby enhances PI3K/AKT pathway activation. |
| Confidence score: |
0.7657 |