| Expression pattern: |
DN |
| Associated gene: |
DICER1 |
| Associated microRNA: |
miR-1184 |
| Biological function: |
hsa_circ_0076798 inhibits M1 macrophage inflammatory response, promotes transformation toward an anti-inflammatory M2 phenotype, and alleviates liver fibrosis. |
| Molecular mechanism: |
hsa_circ_0076798 functions as a miR-1184 sponge, relieves miR-1184-mediated repression of DICER1, and suppresses TNF/NF-kappaB signaling to reduce macrophage inflammation. |
| Biological pathway or process: |
NF-kappaB (inhibits); inflammation (inhibits); fibrosis (inhibits); immune regulation (other); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Microarray; Clinical Sample Validation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; Flow Cytometry（Non-apoptosis/cycle）; In Vivo Animal Model; H&E Staining; IF (Immunofluorescence); Western Blot; RNA-seq; Bioinformatics Analysis |
| Clinical significance: |
hsa_circ_0076798 is significantly reduced in liver fibrosis tissues and may provide a therapeutic target for exosome-based treatment of liver fibrosis. |
| Description: |
hsa_circ_0076798 is a human 3D hESC exosome-enriched circRNA that is reduced in liver fibrosis tissues. It acts as a sponge for miR-1184, increases DICER1 expression, suppresses TNF/NF-kappaB signaling, and reduces M1 macrophage inflammation while promoting anti-inflammatory macrophage features, thereby contributing to alleviation of liver fibrosis. |
| Confidence score: |
0.7893 |