| Expression pattern: |
UP |
| Associated gene: |
E-cadherin, N-cadherin, vimentin |
| Associated microRNA: |
miR-526b |
| Biological function: |
Promotes BCa cell proliferation, migration, invasion, tumor growth and metastasis; promotes EMT-mediated bladder cancer progression. |
| Molecular mechanism: |
circ-0003746 acts as a ceRNA sponge for miR-526b and regulates EMT-related proteins, thereby promoting BCa progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); EMT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; FISH / smFISH; Transfection; EdU Staining; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; IHC (Immunohistochemistry); IF (Immunofluorescence); In Vivo Animal Model; H&E Staining |
| Clinical significance: |
circ-0003746 is associated with tumor progression, including T-stage and N-stage, and may serve as a potential biomarker and therapeutic target for BCa. |
| Description: |
circ-0003746 is a CALD1-derived circRNA up-regulated in bladder cancer tissues and cell lines. It promotes BCa proliferation, migration, invasion, tumor growth and metastasis by sponging miR-526b and activating EMT-related changes. The study suggests circ-0003746 may be a biomarker and therapeutic target for BCa. |
| Confidence score: |
0.8326 |