| Expression pattern: |
UP |
| Associated gene: |
H2AFX |
| Associated microRNA: |
hsa-miR-326, hsa-miR-145-5p |
| Biological function: |
promotes tumour growth and advancement (inferred via hub-gene-centered ceRNA network) |
| Molecular mechanism: |
ceRNA network: included in miR-145-5p/H2AFX axis as an upstream circRNA |
| Biological pathway or process: |
ceRNA regulation (promotes); cell cycle (promotes); angiogenesis (promotes) |
| Detected method: |
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis |
| Clinical significance: |
This circRNA was among upstream circRNAs of the final hub-gene network; hub genes/modules were associated with pathological stage, survival, and B-cell infiltration (circRNA implication is indirect). |
| Description: |
hsa_circRNA_101555 is upregulated in HCC and included in the final ceRNA network as part of the miR-145-5p/H2AFX axis (together with other circRNAs). It is indirectly implicated as a cancer-promoting factor through ceRNA-mediated regulation of a hub gene. |
| Confidence score: |
0.1768 |