circRNA basic information
circBase ID: hsa_circ_0118578
Name: hsa_circ_SATB2
Synonym: hsa_-circ_0118578
Host Gene: SATB2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005075
MONDO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid cancer
Disease DO ID:
 3969
Disease MeSH ID:
 -
Disease NCIt ID:
 C4035
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PTC tissues; adjacent normal tissues
Cell lines:

TPC-1; KTC-1; IHH-4; PTFE
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: EIF4A3, SATB2 pre-mRNA
Associated microRNA: -
Biological function: Promotes PTC cell proliferation, invasion, migration, tumorigenesis, and tumor growth; silencing hsa_circ_0118578 inhibits PTC cell malignancy in vitro and in vivo.
Molecular mechanism: EIF4A3 acts as an RNA-binding protein that binds SATB2 pre-mRNA flanking sequences and enhances/stabilizes hsa_circ_0118578 expression, thereby promoting PTC malignancy.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); other pathway/process (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Transfection; EdU Staining; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; RIP (RNA Immunoprecipitation); Western Blot; Bioinformatics Analysis
Clinical significance:

High hsa_circ_0118578 expression in PTC tissues was associated with higher TNM stage, lymph node metastasis, poor differentiation, and was suggested as a potential therapeutic target.
Description:

hsa_circ_0118578 is upregulated in papillary thyroid cancer and is associated with more aggressive clinicopathologic features. Functionally, hsa_circ_0118578 promotes PTC cell proliferation, invasion, migration, and tumor growth, while its knockdown suppresses malignancy in vitro and in vivo. Mechanistically, EIF4A3 binds SATB2 pre-mRNA flanking sequences and enhances/stabilizes hsa_circ_0118578 expression.
Confidence score:

0.6829
Other information
Title:

EIF4A3-Induced hsa_circ_0118578 Expression Enhances the Tumorigenesis of Papillary Thyroid Cancer.

Journal: Cancer biotherapy & radiopharmaceuticals
Published: 2025
PubMed ID: 39689861
Study type:

combined biological and clinical study
Data availability: GSE173299
Code availability: -