| Expression pattern: |
UP |
| Associated gene: |
NR3C1, Ago2 |
| Associated microRNA: |
miR-1270 |
| Biological function: |
promotes pancreatic cancer cell proliferation, colony formation and migration, inhibits apoptosis, and promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: circ_0128846 sponges miR-1270 to regulate NR3C1 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Western Blot; Clinical Sample Validation; In Vivo Animal Model |
| Clinical significance: |
circ_0128846 expression in advanced tumor node metastasis (TNM) stage was upregulated |
| Description: |
circ_0128846 is up-regulated in pancreatic cancer tissues and cell lines and mainly localized in the cytoplasm. Its knockdown suppresses proliferation, colony formation and migration while promoting apoptosis, and inhibits xenograft tumor growth, partly by sponging miR-1270 to relieve repression of NR3C1. |
| Confidence score: |
0.7827 |