circRNA basic information
circBase ID: hsa_circ_0098181
Name: hsa_circ_SOX5
Synonym: circ_0098181
Host Gene: SOX5
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005155
MONDO name: cirrhosis of liver
Disease details: liver fibrosis
Disease DO ID:
 5082
Disease MeSH ID:
 D008103
Disease NCIt ID:
 C2951
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

human liver tissue
Cell lines:

LX2; HSC-T6
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
DN
Associated gene: PKM2, ADAR1, ICS1, ICS3
Associated microRNA: miR-18a-3p
Biological function: Inhibits HSC activation, proliferation and migration; ameliorates CCl4-induced liver fibrosis; suppresses hepatic inflammation.
Molecular mechanism: circ_0098181 directly binds PKM2, restrains its nuclear translocation and phosphorylation; ADAR1 binds intronic complementary sequences to suppress circ_0098181 biogenesis; circ_0098181 overexpression decreases pro-inflammatory cytokines (e.g., TNF-alpha, Fas, Bcl3, Cxcl11).
Biological pathway or process:

fibrosis (inhibits); inflammation (inhibits); proliferation (inhibits); migration (inhibits); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; FISH / smFISH; RNA Pull-Down; RIP (RNA Immunoprecipitation); Western Blot; Transfection; CCK8; Transwell Assay; Nuclear-Cytoplasmic Fractionation; IF (Immunofluorescence); In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Bioinformatics Analysis
Clinical significance:

-
Description:

circ_0098181 is down-regulated in cirrhotic/fibrotic liver tissues and activated HSCs. Overexpression of circ_0098181 suppresses HSC activation, proliferation, and migration, reduces inflammatory cytokine expression, and ameliorates CCl4-induced liver fibrosis. Mechanistically, it directly binds PKM2 to inhibit PKM2 nuclear translocation/phosphorylation, and its biogenesis is negatively regulated by ADAR1 binding to flanking intronic complementary sequences.
Confidence score:

0.7469
Other information
Title:

Circ_0098181 binds PKM2 to attenuate liver fibrosis.

Journal: Frontiers in pharmacology
Published: 2025
PubMed ID: 40248098
Study type:

combined biological and clinical study
Data availability: https://www.frontiersin.org/articles/10.3389/fphar.2025.1517250/full#supplementary-material
Code availability: -