| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-125b |
| Biological function: |
Promotes HCC cell proliferation and inhibits apoptosis; knockdown attenuates proliferation and increases apoptosis; associated with advanced pathological stage and poor prognosis. |
| Molecular mechanism: |
circ_0006168 functions through sponging/binding microRNA-125b and inhibits microRNA-125b expression, thereby promoting malignant progression of HCC. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (promotes); apoptosis (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; Bioinformatics Analysis; Survival Analysis |
| Clinical significance: |
Elevated circ_0006168 expression is associated with advanced pathological staging, lower overall survival rates, and poor prognosis in HCC patients; it may serve as a potential molecular marker and therapeutic target. |
| Description: |
circ_0006168 is up-regulated in HCC tissues and cell lines and is associated with advanced pathological stage and poor overall survival. Functionally, circ_0006168 promotes HCC cell proliferation and suppresses apoptosis. Mechanistically, it binds and negatively regulates microRNA-125b, contributing to malignant progression of HCC. |
| Confidence score: |
0.7618 |