| Expression pattern: |
UP |
| Associated gene: |
S100A11 |
| Associated microRNA: |
miR-654-5p |
| Biological function: |
Promotes NSCLC proliferation, tumor growth, migration, invasion and pulmonary metastasis; downregulation suppresses malignant progression. |
| Molecular mechanism: |
hsa_circ_0000571 acts through a ceRNA-like mechanism by sponging miR-654-5p and regulating S100A11 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
H
S
|
| Validation methods: |
RNase R Treatment; RT-qPCR; RNA-seq; FISH / smFISH; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ-0000571 expression was positively correlated with TNM stage, pathological grade, high tumor grade, and poor overall survival; circ-0000571 is suggested as a candidate therapeutic target for NSCLC. |
| Description: |
hsa_circ_0000571/circ-0000571 is up-regulated in NSCLC tissues and cell lines and is associated with higher tumor grade, TNM/pathological grade, and poor overall survival. Functionally, circ-0000571 promotes NSCLC proliferation, tumor growth, migration, invasion and pulmonary metastasis. Mechanistically, it acts through the miR-654-5p/S100A11 axis, consistent with a ceRNA-like regulatory model. |
| Confidence score: |
0.8156 |