circRNA basic information
circBase ID: hsa_circ_0068458
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma / OS
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

MG63; MG63/DXR; U2OS; U2OS/DXR; KHOS; KHOS/DXR
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Downregulated in chemoresistant osteosarcoma cell lines; no specific functional mechanism was experimentally characterized.
Molecular mechanism: -
Biological pathway or process:

chemoresistance (other); drug resistance (other)
Detected method:
Q
S
Validation methods:

RNase R Treatment; circRNA-seq; RT-qPCR; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa circ 0068458 was identified as the most downregulated circRNA in chemoresistant osteosarcoma cell lines compared with chemosensitive controls. Its downregulation was validated by qRT-PCR in cell lines, but the study did not further characterize its clinical significance or molecular mechanism.
Confidence score:

0.4276
Other information
Title:

Screening circular RNA related to chemotherapeutic resistance in osteosarcoma by RNA sequencing.

Journal: Epigenomics
Published: 2018
PubMed ID: 30191736
Study type:

biological research
Data availability: -
Code availability: -