| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-1207-5p, hsa-miR-6787-5p, hsa-miR-940, hsa-miR-1202, hsa-miR-4459, hsa-miR-3194-5p |
| Biological function: |
Associated with prognosis in HCC; proposed tumor-suppressive role. |
| Molecular mechanism: |
Bioinformatically predicted association with multiple miRNAs; hypothesized miRNA-mediated regulation. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (other); cell cycle (other); apoptosis (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis; Cohort Study; Bioinformatics Analysis |
| Clinical significance: |
Diagnostic biomarker potential (ROC AUC reported) and prognostic value (lower expression associated with worse prognosis). |
| Description: |
hsa_circ_0078602 is down-regulated in hepatocellular carcinoma tissues versus adjacent non-cancerous tissues. Lower expression is associated with poorer overall survival and it shows diagnostic potential by ROC analysis. Mechanistically, the study reports bioinformatically predicted associations with several miRNAs, but no experimental mechanistic validation. |
| Confidence score: |
0.5734 |