| Expression pattern: |
DN |
| Associated gene: |
CADM1, PI3K/AKT pathway, p-PI3K, PI3K, p-Akt, Akt |
| Associated microRNA: |
miR-224 |
| Biological function: |
Down-regulated in cervical cancer tissues and cell lines; higher expression is associated with favorable clinicopathological features and longer survival; m6A-adjusted hsa_circ_0101308 restrains viability and chemo-resistance of drug-resistant cervical cancer cells by sponging miR-224. |
| Molecular mechanism: |
m6A-adjusted hsa_circ_0101308 acts as a miR-224 sponge; miR-224 targets CADM1, thereby regulating the PI3K/AKT pathway and modifying multidrug resistance in cervical cancer. |
| Biological pathway or process: |
PI3K/AKT (inhibits); drug resistance (inhibits); chemoresistance (inhibits); ceRNA regulation (other); m6A modification (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; MeRIP / MeRIP-seq; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; MTT; Survival Analysis; Bioinformatics Analysis; Cohort Study |
| Clinical significance: |
High hsa_circ_0101308 expression was associated with fine/moderate differentiation, FIGO stage IA&IB, lymph node non-metastasis, vascular non-invasion, and longer 2-year overall survival in cervical cancer patients. |
| Description: |
hsa_circ_0101308 is down-regulated in cervical cancer tissues and cell lines. The study indicates that m6A-adjusted hsa_circ_0101308 suppresses drug-resistant cervical cancer cell viability and chemo-resistance by sponging miR-224, thereby affecting the miR-224/CADM1/PI3K-AKT pathway. Clinically, higher hsa_circ_0101308 expression is associated with favorable pathological features and better 2-year overall survival. |
| Confidence score: |
0.7682 |