circRNA basic information
circBase ID: hsa_circ_0031968
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr14:53331118-53331571:-
Genomic location(hg38): chr14:52864400-52864853:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma / LUAD
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; normal adjacent tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: GCG, FUS, eIF4AIII, PTB, U2AF65, UPF1, AGO2, HuR, IGF2BP3, IGF2BP1, IGF2BP2, LIN28A, LIN28B
Associated microRNA: miR-3611, miR-548
Biological function: May play an essential regulatory role in the occurrence and development of LUAD.
Molecular mechanism: ceRNA mechanism via the hsa_circ_0031968/miR-3611/GCG axis.
Biological pathway or process:

ceRNA regulation (other); Wnt/beta-catenin (other); p53 signaling (other); proliferation (other); migration (other); invasion (other); apoptosis (other); stemness (other); cell cycle (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

May be used as new insights of LUAD biomarkers; predictive value unclear.
Description:

hsa_circ_0031968 is down-regulated in LUAD tissues and was proposed to act in a ceRNA network by regulating miR-3611 to affect the target gene GCG. The study suggests this axis may contribute to LUAD pathogenesis and could provide biomarker clues, but the circRNA’s predictive value requires further experimental validation.
Confidence score:

0.4032
Other information
Title:

Construction and analysis of the ceRNA network hsa_circ_0031968/miR-3611/GCG in lung adenocarcinoma.

Journal: Annals of translational medicine
Published: 2021
PubMed ID: 35071451
Study type:

combined biological and clinical study
Data availability: GSE101684; GSE135918; TCGA
Code availability: -