| Expression pattern: |
UP |
| Associated gene: |
EZH2 |
| Associated microRNA: |
miR-144-3p |
| Biological function: |
promotes proliferation, migration, invasion, and EMT of gastric cancer cells |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-144-3p to regulate EZH2 expression (ceRNA mechanism), thereby promoting malignant behaviors and EMT in gastric cancer cells. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; MTT; Transwell Assay; Western Blot; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
high intratumoral circKIF4A expression predicted a poor prognosis in GC patients; associated with larger tumor size and advanced TNM stage |
| Description: |
circKIF4A is up-regulated in gastric cancer and promotes proliferation, migration, invasion, and EMT. It mainly localizes to the cytoplasm and acts as a ceRNA by sponging miR-144-3p to increase EZH2, and higher circKIF4A expression is associated with poorer overall survival. |
| Confidence score: |
0.7325 |