| Expression pattern: |
DN |
| Associated gene: |
FGF10 |
| Associated microRNA: |
hsa-miR-145-5p |
| Biological function: |
May be involved in proliferation, migration, and invasion of GC (via the proposed ceRNA network). |
| Molecular mechanism: |
ceRNA network (circRNA-miRNA-immune-related mRNA) involving hsa-miR-145-5p and FGF10; associated with Rap1 and Ras signaling pathways. |
| Biological pathway or process: |
Rap1 signaling (other); Ras signaling (other); proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
hsa_circ_0003763 is down-regulated in gastric cancer and is part of a proposed ceRNA subnetwork hsa_circ_0003763-hsa-miR-145-5p-FGF10. The authors suggest this network may contribute to GC proliferation, migration, and invasion, potentially involving Rap1 and Ras signaling. |
| Confidence score: |
0.4032 |