circRNA basic information
circBase ID: -
Name: hsa_circ_TTC3
Synonym: circRNA46342
Host Gene: TTC3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

HPV negative normal cervical epithelium; HPV16 positive normal cervical epithelium; HPV16 positive high-grade squamous intraepithelial lesion; HPV16 positive cervical squamous epithelial cell carcinoma tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: NOP56, ELAVL1, NUMA1, FAM120A, CELF2, UPF1, TAF15, FMR1, DGCR8, SRSF7, SRSF1, NOP58, U2AF1, ADAR, U2AF2, SRSF9, DDX54, RBM10, PCBP2, HNRNPM, HNRNPC, DDX3X, SMNDC1, HNRNPA1, FXR2, IGF2BP1, IGF2BP3, IGF2BP2, RBFOX2, SLTM, DDX42, CSTF2T, EIF4A3, FBL
Associated microRNA: hsa-miR-22-5p
Biological function: Potential ceRNA involved in cervical cancer progression.
Molecular mechanism: Predicted ceRNA mechanism via hsa-miR-22-5p and predicted RBP interactions.
Biological pathway or process:

ceRNA regulation (other); other pathway/process (other)
Detected method:
S
Validation methods:

Bioinformatics Analysis; RNA-seq
Clinical significance:

Potential prognostic and diagnostic pan-cancer signature and potential cervical cancer progression marker.
Description:

circRNA46342/hsa-TTC3_0004 was identified as an up-regulated DE circRNA and predicted to bind hsa-miR-22-5p. The study proposed that this interaction may alter ribonucleoprotein complexes and the cellular transcriptome in cervical cancer progression.
Confidence score:

0.1768
Other information
Title:

Exploring the role of circRNA-miRNA-mRNA interactions in cervical cancer progression: insights into HPV status and potential therapeutic approaches.

Journal: Journal of applied genetics
Published: 2025
PubMed ID: 40531429
Study type:

bioinformatics study
Data availability: GSE147009; TCGA; CircAtlas; Transcirc; MiRWalk 3.0; CMAP2; CTDBASE
Code availability: -