circRNA basic information
circBase ID: hsa_circ_0077210
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr6:83933478-83938650:-
Genomic location(hg38): chr6:83223759-83228931:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; normal liver tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: CPEB3, ACADL
Associated microRNA: hsa-miR-92b-3p
Biological function: inhibits the occurrence and progression of HCC (tumor suppression axis)
Molecular mechanism: ceRNA regulatory network: hsa_circ_0077210 as an upstream regulatory molecule of hsa-miR-92b-3p affecting CPEB3 and ACADL
Biological pathway or process:

ceRNA regulation (other); cell cycle (inhibits); PI3K/AKT/mTOR (inhibits); Wnt/beta-catenin (inhibits)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

This study identified hsa_circ_0077210 as an upstream regulator in an HCC ceRNA axis, potentially modulating hsa-miR-92b-3p and downstream targets CPEB3 and ACADL. The axis is proposed to inhibit HCC occurrence and progression and was supported by differential expression in clinical HCC tissues.
Confidence score:

0.4032
Other information
Title:

Construction of circRNA-Based ceRNA Network to Reveal the Role of circRNAs in the Progression and Prognosis of Hepatocellular Carcinoma.

Journal: Frontiers in genetics
Published: 2021
PubMed ID: 33719338
Study type:

combined biological and clinical study
Data availability: TCGA-LIHC; GSE94508; https://www.frontiersin.org/articles/10.3389/fgene.2021.626764/full#supplementary-material
Code availability: -