circRNA basic information
circBase ID: -
Name: hsa_circ_ESR1
Synonym: circRNA4402
Host Gene: ESR1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

HPV negative normal cervical epithelium; HPV16 positive normal cervical epithelium; HPV16 positive high-grade squamous intraepithelial lesion; HPV16 positive cervical squamous epithelial cell carcinoma tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: WDR33, ACIN1, U2AF2, MOV10, ELAVL1, NOP56, CSTF2T, LIN28B, DDX54, CSTF2, FUS, TARDBP, TAF15, FIP1L1, PTBP1, HNRNPC, NOP58
Associated microRNA: hsa-miR-24-3p, hsa-miR-96-3p
Biological function: Potential ceRNA involved in cervical cancer progression.
Molecular mechanism: Predicted ceRNA mechanism via hsa-miR-24-3p and hsa-miR-96-3p; predicted RBP interactions.
Biological pathway or process:

ceRNA regulation (other); other pathway/process (other)
Detected method:
S
Validation methods:

Bioinformatics Analysis; RNA-seq
Clinical significance:

Potential biomarker and therapeutic target for cervical cancer progression.
Description:

circRNA4402/hsa-ESR1_0005 was identified as a down-regulated DE circRNA in cervical cancer progression. It was predicted to bind hsa-miR-24-3p and hsa-miR-96-3p and to participate in a broader circRNA-miRNA-mRNA ceRNA network.
Confidence score:

0.1768
Other information
Title:

Exploring the role of circRNA-miRNA-mRNA interactions in cervical cancer progression: insights into HPV status and potential therapeutic approaches.

Journal: Journal of applied genetics
Published: 2025
PubMed ID: 40531429
Study type:

bioinformatics study
Data availability: GSE147009; TCGA; CircAtlas; Transcirc; MiRWalk 3.0; CMAP2; CTDBASE
Code availability: -