| Expression pattern: |
UP |
| Associated gene: |
lysophosphatidylcholine acyltransferase 1 (LPCAT1) |
| Associated microRNA: |
miR-579-3p, miR-623, miR-1197, miR-1304, miR-548l, miR-605, miR-935 |
| Biological function: |
- |
| Molecular mechanism: |
- |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; divergent primers PCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; Bioinformatics Analysis; ROC Analysis |
| Clinical significance: |
Included in a 10-circRNA signature able to discriminate LC from controls (AUC ROC 0.86). |
| Description: |
circZCCHC6 is up-regulated in plasma EV-enriched samples from early-stage NSCLC patients and was experimentally validated by RT-qPCR with divergent primers and junction confirmation by Sanger sequencing. It is also included in a 10-circRNA machine-learning signature (AUC ROC 0.86) for discriminating NSCLC from controls; the paper notes reported/putative miRNA interactions and a previously described circZCCHC6-miR-433-3p-LPCAT1 regulatory relationship. |
| Confidence score: |
0.6548 |