circRNA basic information
circBase ID: hsa_circ_0008039
Name: hsa_circ_PRKAR1B
Synonym: -
Host Gene: PRKAR1B
Genomic location(hg19): chr7:716865-751164:-
Genomic location(hg38): chr7:677228-711527:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: stage II/III colon cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

frozen tumor tissues; adjacent normal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing
Clinical significance:

Included in a four-circRNA-based cirScore that stratifies recurrence risk and is associated with shorter DFS and OS in high-risk (high cirScore) patients.
Description:

hsa_circ_0008039 is one of four circRNAs forming a prognostic cirScore for stage II/III colon cancer; higher cirScore predicts worse DFS/OS and higher recurrence risk. The study validates its circularity and expression for use in the classifier, but does not report a dedicated functional mechanism for this circRNA.
Confidence score:

0.7278
Other information
Title:

A circRNA signature predicts postoperative recurrence in stage II/III colon cancer.

Journal: EMBO molecular medicine
Published: 2019
PubMed ID: 31475771
Study type:

combined biological and clinical study
Data availability: SRA551560 (PRJNA551560); PRJCA001113
Code availability: https://github.com/likelet/CircRNA_colon_recurrent_prediction; https://github.com/likelet/RNAseqPipe