circRNA basic information
circBase ID: hsa_circ_0079929
Name: hsa_circ_CDK13
Synonym: hsa_circCDK13_005 / CircCDK13
Host Gene: CDK13
Genomic location(hg19): chr7:40027197-40027857:+
Genomic location(hg38): chr7:39987598-39988258:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma / LUAD
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

lung adenocarcinoma tissues; adjacent normal lung tissues
Cell lines:

MRC-5; HFL1; Calu-3; PC-9; NCI-H1975; NCI-H1395
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-1184
Biological function: promotes proliferation, migration and invasion of lung adenocarcinoma cells
Molecular mechanism: acts as a miRNA sponge/decoy for miR-1184 (ceRNA-like mechanism)
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Clinical Sample Validation; Cohort Study; Survival Analysis; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; Bioinformatics Analysis
Clinical significance:

Upregulation of hsa_circ_0079929 was correlated with adverse clinical parameters and poor outcome in terms of overall survival, resulting in an independent prognostic purpose molecular for overall survival.
Description:

hsa_circ_0079929 is up-regulated in lung adenocarcinoma tissues and cell lines and correlates with advanced clinicopathologic features and worse overall survival. Functionally, it promotes proliferation, migration, and invasion in LUAD cells. Mechanistically, it acts as a miR-1184 sponge/decoy, and miR-1184 inhibition rescues the effects of hsa_circ_0079929 knockdown.
Confidence score:

0.7785
Other information
Title:

Hsa_circ_0079929 in lung adenocarcinoma and its biological implications in lung adenocarcinoma progression.

Journal: Journal of cardiothoracic surgery
Published: 2024
PubMed ID: 39342367
Study type:

combined biological and clinical study
Data availability: No datasets were generated or analysed during the current study.
Code availability: -