circRNA basic information
circBase ID: -
Name: hsa_circ_AXIN1
Synonym: circRNA AXIN1
Host Gene: AXIN1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005148
MONDO name: type 2 diabetes mellitus
Disease details: Type 2 diabetes mellitus / T2DM
Disease DO ID:
 9352
Disease MeSH ID:
 D003924
Disease NCIt ID:
 C26747
Disease ICD11 ID:
 119724091
Disease OMIM ID:
 125853
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: -
Associated microRNA: -
Biological function: Associated with the progression of diabetes.
Molecular mechanism: Predicted circRNA-miRNA-mRNA ceRNA regulatory network (bioinformatics prediction); specific mechanism for circRNA AXIN1 not experimentally validated.
Biological pathway or process:

ceRNA regulation (other); insulin signalling (other); other pathway/process (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

Expression of circRNA AXIN1 was associated with the progression of diabetes.
Description:

Serum circRNA AXIN1 is identified as differentially expressed between DM/T2DM and NDM groups by RNA-seq and is reported to be associated with diabetes progression. It is included in a predicted circRNA-miRNA-mRNA (ceRNA) network, but the paper provides no circRNA-specific experimental validation of mechanism.
Confidence score:

0.1768
Other information
Title:

Analysis of circRNA-mRNA expression profiles and functional enrichment in diabetes mellitus based on high throughput sequencing.

Journal: International wound journal
Published: 2022
PubMed ID: 35504843
Study type:

combined biological and clinical study
Data availability: The datasets generated and analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -