| Expression pattern: |
DN |
| Associated gene: |
SGTB, Ago2 |
| Associated microRNA: |
miR-942-5p |
| Biological function: |
Suppresses proliferation, migration and invasion; promotes apoptosis; inhibits tumor growth in vivo |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-942-5p to regulate SGTB expression |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); metastasis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Sanger Sequencing; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; MTT; EdU Staining; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; IHC (Immunohistochemistry); Clinical Sample Validation; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Low expression level of circ_0102543 was significantly correlated with the advance TNM stage, lymph node metastasis, and fibrosis; the overall survival rate of the high circ_0102543 expression group was significantly higher than that of the group with low circ_0102543 expression. |
| Description: |
circ_0102543 is down-regulated in HCC tissues/cell lines and functions as a tumor suppressor. It sponges miR-942-5p to de-repress SGTB, thereby inhibiting proliferation, migration, and invasion while promoting apoptosis, and it reduces xenograft tumor growth. |
| Confidence score: |
0.8465 |