| Expression pattern: |
UP |
| Associated gene: |
placental DNA |
| Associated microRNA: |
- |
| Biological function: |
Facilitates DNA damage and induces cellular senescence in primary human syncytiotrophoblasts; knockdown reduces DNA damage and senescence-associated gene expression. |
| Molecular mechanism: |
circ_0000284 binds placental DNA to form circR-loops, facilitating DNA breaks and cellular senescence; accumulation may be linked to decreased RNase H1-mediated degradation. |
| Biological pathway or process: |
other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Transfection |
| Clinical significance: |
- |
| Description: |
hsa_circ_0000284 is increased in stillbirth placentae and is the mechanistically validated circRNA in this study. It forms circR-loops in primary syncytiotrophoblasts, and its knockdown reduces DNA damage and senescence-associated gene expression, supporting a role in placental aging and stillbirth pathogenesis. |
| Confidence score: |
0.5917 |