| Expression pattern: |
UP |
| Associated gene: |
ATXN7L3 |
| Associated microRNA: |
miR-503-5p |
| Biological function: |
circ_0085616 promotes cervical cancer cell proliferation, migration, invasion, glycolysis, and tumorigenesis in vivo. |
| Molecular mechanism: |
circ_0085616 acts as a miR-503-5p sponge to enhance ATXN7L3 expression, thereby promoting cervical cancer progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); glycolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MTT; Colony Formation Assay; Transwell Assay; Western Blot; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model |
| Clinical significance: |
circ_0085616 may be an effective target in the diagnosis and treatment of cervical cancer. |
| Description: |
circ_0085616 is up-regulated in cervical cancer tissues and cell lines. It promotes proliferation, migration, invasion, glycolysis, and in vivo tumor growth by sponging miR-503-5p and activating ATXN7L3, suggesting potential diagnostic and therapeutic relevance. |
| Confidence score: |
0.7045 |