circRNA basic information
circBase ID: hsa_circ_0002968
Name: -
Synonym: circ_0002968
Host Gene: -
Genomic location(hg19): chr10:49609654-49618211:+
Genomic location(hg38): chr10:48401611-48410168:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

paired gastric cancer and normal tissues; gastric cancer specimens; normal tissues
Cell lines:

MKN-45; gastric cancer cells
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: circPDIA4
Associated microRNA: -
Biological function: Identified as a circPDIA4-induced oncogenic candidate circRNA up-regulated in gastric cancer tissues; individual functional assays were not reported.
Molecular mechanism: Up-regulated downstream of circPDIA4-controlled circRNA biogenesis; positively correlated with circPDIA4 expression in gastric tissues.
Biological pathway or process:

other pathway/process (promotes)
Detected method:
Q
S
Validation methods:

circRNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

circ_0002968 is up-regulated in gastric cancer specimens and positively correlated with circPDIA4 expression.
Description:

circ_0002968 is one of the circPDIA4-induced candidate oncogenic circRNAs and is up-regulated in gastric cancer tissues. The paper reports expression validation and correlation with circPDIA4, but does not report individual functional assays for this circRNA.
Confidence score:

0.4685
Other information
Title:

CircPDIA4 Induces Gastric Cancer Progression by Promoting ERK1/2 Activation and Enhancing Biogenesis of Oncogenic circRNAs.

Journal: Cancer research
Published: 2023
PubMed ID: 36562654
Study type:

combined biological and clinical study
Data availability: Genome Sequence Archive-human HRA002373; https://ngdc.cncb.ac.cn/gsa-human/
Code availability: -