| Expression pattern: |
UP |
| Associated gene: |
SPAG5 |
| Associated microRNA: |
miR-1179 |
| Biological function: |
promotes HCC cell proliferation, migration, invasion and xenograft tumor growth |
| Molecular mechanism: |
ceRNA mechanism: circFOXM1 sponges miR-1179 to upregulate SPAG5 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circFOXM1 is upregulated in HCC cells/tissues and functions as an oncogenic circRNA. It promotes proliferation and metastatic phenotypes by sponging miR-1179, thereby increasing SPAG5 expression, and enhances xenograft tumor growth. |
| Confidence score: |
0.7581 |