circRNA basic information
circBase ID: -
Name: hsa_circ_ADAM22
Synonym: circADAM22
Host Gene: ADAM22
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004985
MONDO name: bipolar disorder
Disease details: bipolar disorder
Disease DO ID:
 3312
Disease MeSH ID:
 D001714
Disease NCIt ID:
 C34423
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

orbitofrontal cortex (OFC)
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: unknown
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; RNase R Treatment; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Clinical Sample Validation
Clinical significance:

circADAM22 is downregulated in BD OFC (validated by qRT-PCR).
Description:

circADAM22 (from ADAM22) is significantly down-regulated in the orbitofrontal cortex of bipolar disorder patients in this study, based on microarray screening followed by qRT-PCR validation.
Confidence score:

0.5909
Other information
Title:

A psychiatric disease-related circular RNA controls synaptic gene expression and cognition.

Journal: Molecular psychiatry
Published: 2020
PubMed ID: 31988434
Study type:

combined biological and clinical study
Data availability: https://data.mendeley.com/datasets/9zdhc6pmx5/1
Code availability: -