circRNA basic information
circBase ID: -
Name: hsa_circ_SOD2
Synonym: circSOD2
Host Gene: SOD2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005086
MONDO name: renal cell carcinoma
Disease details: renal cell carcinoma / RCC
Disease DO ID:
 4450
Disease MeSH ID:
 D002292
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

urinary sediment
Cell lines:

HEK 293
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Potential diagnostic biomarker for early detection of ccRCC.
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Detected circSOD2 levels had an AUC of 0.68 for separating cancer patients versus non-neoplastic patients.
Description:

circSOD2 is detectable in urinary sediment and is down-regulated in urine from ccRCC patients compared with healthy controls (also lower in benign tumors vs controls). Urinary circSOD2 has diagnostic value for distinguishing cancer vs non-neoplastic individuals (AUC 0.68).
Confidence score:

0.6238
Other information
Title:

Investigating Urinary Circular RNA Biomarkers for Improved Detection of Renal Cell Carcinoma.

Journal: Frontiers in oncology
Published: 2021
PubMed ID: 35174071
Study type:

combined biological and clinical study
Data availability: https://www.frontiersin.org/articles/10.3389/fonc.2021.814228/full#supplementary-material
Code availability: -