| Expression pattern: |
DN |
| Associated gene: |
FMO2 |
| Associated microRNA: |
miR-421 |
| Biological function: |
Suppresses paclitaxel resistance and malignant cellular behaviors (proliferation, migration/invasion) and promotes apoptosis in PTX-resistant lung adenocarcinoma cells. |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-421 to upregulate FMO2, thereby increasing PTX sensitivity. |
| Biological pathway or process: |
ceRNA regulation (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); drug resistance (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Actinomycin D / DRB Stability Assay; Transfection; MTT; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; Bioinformatics Analysis; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circ_MACF1 shows promise to become an excellent therapeutic biomarker in LADC with PTX treatment. |
| Description: |
circ_MACF1 is down-regulated in paclitaxel-resistant lung adenocarcinoma and functions as a tumor-suppressive, chemosensitizing circRNA. It sponges miR-421 to relieve repression of FMO2, thereby reducing PTX resistance and inhibiting proliferation/motility while promoting apoptosis, including in a cell line-derived xenograft model. |
| Confidence score: |
0.7183 |