| Expression pattern: |
UP |
| Associated gene: |
KPNA2 |
| Associated microRNA: |
miR-495-3p |
| Biological function: |
circ-C20orf11 promotes NSCLC cell proliferation, migration and invasion, inhibits apoptosis, and contributes to NSCLC development. |
| Molecular mechanism: |
circ-C20orf11 acts as a miRNA sponge for miR-495-3p to promote KPNA2 expression, thereby accelerating NSCLC progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
circ-C20orf11 was associated with TNM staging and lymph node metastasis, and high expression predicted unfavorable prognosis in NSCLC patients. |
| Description: |
circ-C20orf11 is up-regulated in NSCLC tissues and cell lines and is associated with TNM stage, lymph node metastasis, and poor prognosis. Functionally, it promotes NSCLC cell proliferation, migration and invasion while inhibiting apoptosis. Mechanistically, circ-C20orf11 sponges miR-495-3p to increase KPNA2 expression, forming a circ-C20orf11/miR-495-3p/KPNA2 axis that accelerates NSCLC progression. |
| Confidence score: |
0.7412 |