| Expression pattern: |
UP |
| Associated gene: |
REV3L, P-gp, GST-pi |
| Associated microRNA: |
miR-4458 |
| Biological function: |
circ-PRMT5 promotes DDP resistance, cell viability, invasion, metastasis-related phenotypes, and tumor growth, while suppressing apoptosis and DDP sensitivity in DDP-resistant NSCLC. |
| Molecular mechanism: |
circ-PRMT5 functions as a ceRNA by sponging miR-4458 to regulate REV3L, thereby promoting cisplatin resistance in NSCLC. |
| Biological pathway or process: |
apoptosis (inhibits); invasion (promotes); metastasis (promotes); chemoresistance (promotes); drug resistance (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
circ-PRMT5 may provide a novel therapeutic strategy and might serve as a novel thought in the diagnosis and prognosis of NSCLC. |
| Description: |
This study found that circ-PRMT5 is up-regulated in cisplatin-resistant NSCLC tissues and cells. Functionally, circ-PRMT5 promotes DDP resistance, invasion, and tumor growth and inhibits apoptosis by acting as a sponge for miR-4458 to up-regulate REV3L. |
| Confidence score: |
0.7177 |