| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-326 |
| Biological function: |
circSATB2 is highly expressed in NSCLC and lung cancer tissues; knockdown inhibits proliferation, migration, and invasion of NSCLC cells and decelerates disease progression; circSATB2 expression correlates positively with lung cancer progression and tumor size. |
| Molecular mechanism: |
circSATB2 acts as a sponge to adsorb and reduce the concentration of tumor suppressor miR-326, thereby promoting NSCLC progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; ROC Analysis |
| Clinical significance: |
circSATB2 can act as a biomarker to distinguish healthy donors from lung cancer patients and to identify different stages and subtypes of lung cancer; its expression positively correlates with disease progression and tumor size. |
| Description: |
This study uses a palindrome-crosslinked DNA nanoaggregate fluorescence system and qRT-PCR to detect circSATB2 in lung cancer cells and clinical lung cancer tissues. circSATB2 is up-regulated in lung cancer, negatively regulates miR-326, and is associated with NSCLC progression-related proliferation, migration, and invasion. Clinically, circSATB2 shows diagnostic value for distinguishing healthy donors from lung cancer patients and for classifying disease stages and subtypes. |
| Confidence score: |
0.5127 |