circRNA basic information
circBase ID: hsa_circ_0019120
Name: hsa_circ_BTAF1
Synonym: hsa_circBTAF1_002
Host Gene: BTAF1
Genomic location(hg19): chr10:93699708-93702325:+
Genomic location(hg38): chr10:91939951-91942568:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

blood; platelets
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential non-invasive diagnostic biomarker for colorectal cancer and advanced polyp risk assessment and early detection
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

hsa_circ_0019120 showed diagnostic potential for distinguishing advanced polyp and CRC patients from healthy controls, with AUC of 0.739 for advanced polyps and 0.717 for CRC; combined with hsa_circ_0004771, AUC was 0.8348 with sensitivity of 84% and specificity of 80%.
Description:

Platelet-derived hsa_circ_0019120 was significantly upregulated in both advanced polyp patients and CRC patients compared with healthy controls. The study supports its potential as a non-invasive biomarker for CRC and advanced polyp risk assessment and early detection, including combined diagnostic use with hsa_circ_0004771.
Confidence score:

0.4187
Other information
Title:

Platelet-Derived circRNAs hsa_circ_0004771 and hsa_circ_0019120 Differentially Expressed in Colorectal Cancer and Polyps.

Journal: Reports of biochemistry & molecular biology
Published: 2024
PubMed ID: 40330565
Study type:

clinical study
Data availability: -
Code availability: -