circRNA basic information
circBase ID: hsa_circ_0006990
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr18:9931806-9937063:+
Genomic location(hg38): chr18:9931809-9937066:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; adjacent non-cancerous tissues / paracancerous tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: PLOD2, TARS, RNF19B, CCT2, RAN, C5orf30, MCM10
Associated microRNA: -
Biological function: May play key roles in the progression/development of HCC.
Molecular mechanism: circRNA-associated ceRNA network (predicted).
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
M
Validation methods:

Microarray; RNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Identified as a key hub circRNA in the HCC ceRNA network and proposed as a prognostic biomarker.
Description:

hsa_circ_0006990 was highlighted as a hub circRNA in an HCC ceRNA network and was validated as differentially expressed between HCC tumors and paracancerous tissues, suggesting involvement in HCC progression.
Confidence score:

0.4297
Other information
Title:

Detection of Prognostic Biomarkers for Hepatocellular Carcinoma through CircRNA-associated CeRNA Analysis.

Journal: Journal of clinical and translational hepatology
Published: 2022
PubMed ID: 35233376
Study type:

combined biological and clinical study
Data availability: GSE125469; TCGA
Code availability: -