| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Diagnostic biomarker candidate; circFOXO3 was measured at lower levels in breast cancer tissues than in healthy tissues and was evaluated for distinguishing breast cancer patients from healthy individuals. |
| Molecular mechanism: |
- |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis |
| Clinical significance: |
circFOXO3 was downregulated in breast cancer tissues and showed diagnostic performance for distinguishing breast cancer patients from healthy individuals; AUC value of the single-molecule biosensor was 1. |
| Description: |
This study used a ligation-controlled single-molecule biosensor and qRT-PCR to measure circFOXO3 in human cells and breast tissues. circFOXO3 was downregulated in breast cancer tissues compared with healthy tissues and was evaluated as a diagnostic marker with ROC analysis. |
| Confidence score: |
0.4187 |