circRNA basic information
circBase ID: -
Name: hsa_circ_HIPK3
Synonym: circHIPK3
Host Gene: HIPK3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: nucleus and cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008903
MONDO name: lung cancer
Disease details: lung cancer
Disease DO ID:
 1324
Disease MeSH ID:
 -
Disease NCIt ID:
 C7377
Disease ICD11 ID:
 -
Disease OMIM ID:
 211980
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue; para-cancerous tissue; normal lung tissue adjacent to cancer
Cell lines:

A549; A549/GR
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Low expression of circHIPK3 enhances gefitinib resistance in lung adenocarcinoma cells; associated with decreased gefitinib-mediated apoptosis in drug-resistant cells.
Molecular mechanism: Not specified in this study (mechanism to be clarified).
Biological pathway or process:

drug resistance (promotes); apoptosis (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Back-Splice Junction PCR / divergent primers PCR; Clinical Sample Validation; Annexin V/PI Flow Cytometry; MTT; ROC Analysis
Clinical significance:

circHIPK3 had high diagnostic value for lung cancer (ROC curve; high sensitivity and specificity).
Description:

circHIPK3 is down-regulated in lung cancer tissues and is associated with more advanced tumor characteristics (larger tumor diameter, higher TNM stage, lymph node metastasis). Reduced circHIPK3 expression is linked to enhanced gefitinib resistance in lung adenocarcinoma cells, accompanied by decreased gefitinib-mediated apoptosis, and circHIPK3 shows diagnostic potential by ROC analysis.
Confidence score:

0.7035
Other information
Title:

Mechanism of RNA circHIPK3 Involved in Resistance of Lung Cancer Cells to Gefitinib.

Journal: BioMed research international
Published: 2022
PubMed ID: 35496045
Study type:

combined biological and clinical study
Data availability: The data used to support the findings of this study are included within the article.
Code availability: -