| Expression pattern: |
UP |
| Associated gene: |
HNRNPC, AGO2 |
| Associated microRNA: |
miR-185-5p |
| Biological function: |
Promotes NSCLC cell proliferation, migration, invasion, tumor growth, lung metastasis and cisplatin resistance, while inhibiting apoptosis and reducing cisplatin sensitivity. |
| Molecular mechanism: |
circFUT8 acts as a ceRNA that sponges miR-185-5p to relieve miR-185-5p-mediated repression of HNRNPC, increasing HNRNPC expression in an M6A-linked regulatory network. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); chemoresistance (promotes); drug resistance (promotes); m6A modification (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Microarray; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; FISH / smFISH; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model; H&E Staining |
| Clinical significance: |
circFUT8 is proposed as a potential target to overcome chemoresistance in NSCLC; previous reports cited in the article state that circFUT8 upregulation correlates with tumor metastasis, disease recurrence, and lower patient survival rates. |
| Description: |
circFUT8 is upregulated in NSCLC and promotes malignant phenotypes and cisplatin resistance. Mechanistically, it sponges miR-185-5p to upregulate the M6A reader HNRNPC, thereby promoting proliferation, migration, invasion, tumor growth and lung metastasis while suppressing apoptosis and cisplatin sensitivity. |
| Confidence score: |
0.7634 |