| Expression pattern: |
DN |
| Associated gene: |
LPHN3, BNC2, CGNL1, ZNF208 |
| Associated microRNA: |
hsa-miR-342-3p, hsa-miR-324-3p |
| Biological function: |
Promotes fibroblast proliferation and is associated with tumor-associated fibroblast infiltration in cervical cancer. |
| Molecular mechanism: |
ceRNA mechanism in which circZNF208 sponges miRNA and regulates downstream mRNAs, especially the circ_ZNF208/hsa-miR-342-3p/LPHN3 axis. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (promotes); immune regulation (other); other pathway/process (other) |
| Detected method: |
S
|
| Validation methods: |
circRNA-seq; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
May affect prognosis of cervical cancer patients through regulation of fibroblast proliferation; may act as a target molecule of cervical cancer therapy. |
| Description: |
circZNF208 is a novel circRNA identified by circRNA-seq as down-regulated in cervical cancer tissues compared with adjacent tissues. The study proposes that circZNF208 participates in a ceRNA network, especially the circ_ZNF208/hsa-miR-342-3p/LPHN3 axis, and may promote fibroblast proliferation and influence tumor-associated fibroblast-related prognosis in cervical cancer. |
| Confidence score: |
0.3991 |