circRNA basic information
circBase ID: hsa_circ_0000369
Name: hsa_circ_FLI1
Synonym: -
Host Gene: FLI1
Genomic location(hg19): chr11:128628009-128642880:+
Genomic location(hg38): chr11:128758114-128772985:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

PBMCs
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential diagnostic biomarker for HCC.
Molecular mechanism: Predicted circRNA-miRNA-mRNA regulatory network (bioinformatics).
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Potential diagnostic biomarker for HCC (high ROC AUC).
Description:

hsa_circ_0000369 is up-regulated in PBMCs from HCC patients and validated by RT-qPCR. It shows high diagnostic potential (high ROC AUC) and is included in predicted circRNA-miRNA-mRNA networks.
Confidence score:

0.5047
Other information
Title:

CircRNA expression profiling of PBMCs from patients with hepatocellular carcinoma by RNA-sequencing.

Journal: Experimental and therapeutic medicine
Published: 2021
PubMed ID: 34737807
Study type:

combined biological and clinical study
Data availability: PRJNA754685
Code availability: -