| Expression pattern: |
UP |
| Associated gene: |
ZEB1 |
| Associated microRNA: |
miR-873-5p |
| Biological function: |
Promotes proliferation, invasion, and migration (tumorigenic behavior) in gastric cancer cells. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-873-5p, thereby relieving inhibition on ZEB1 and increasing ZEB1 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Western Blot; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
May be useful as a biomarker and target for diagnosing and treating gastric cancer. |
| Description: |
hsa_circ_0005529 is up-regulated in gastric cancer tissues and GC cell lines and mainly localizes to the cytoplasm. It promotes proliferation, migration, and invasion by sponging miR-873-5p and thereby increasing ZEB1 expression via a hsa_circ_0005529/miR-873-5p/ZEB1 axis. |
| Confidence score: |
0.7519 |