| Expression pattern: |
UP |
| Associated gene: |
mRNAs in ceRNA network |
| Associated microRNA: |
- |
| Biological function: |
Promotes NSCLC cell growth, migration, invasion, and colony formation and inhibits apoptosis; identified as a diagnostic biomarker and potential drug target. |
| Molecular mechanism: |
Bioinformatically constructed ceRNA network; knockdown experiments supported an oncogenic role in NSCLC cells, but the ceRNA regulatory mechanism was not experimentally validated. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other); other pathway/process (other); immune regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Colony Formation Assay |
| Clinical significance: |
Potential diagnostic biomarker for NSCLC with AUC > 0.85; included in a nomogram model for patients with NSCLC; proposed as an effective drug target in NSCLC. |
| Description: |
hsa_circ_0084443 was upregulated in NSCLC tumor tissues and NSCLC cell lines. Knockdown experiments in A549 cells showed that it promotes malignant cell behaviors, including growth, migration, invasion, and colony formation, while suppressing apoptosis; it was also incorporated into a predicted ceRNA network and proposed as a potential drug target. |
| Confidence score: |
0.6458 |