circRNA basic information
circBase ID: hsa_circ_0067772
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr3:155547476-155560408:-
Genomic location(hg38): chr3:155829687-155842619:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma; breast cancer tissues; matched adjacent normal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Circulating diagnostic biomarker candidate for breast cancer (part of the three-circRNA diagnostic model).
Molecular mechanism: Predicted miRNA sponging with downstream pathway involvement based on bioinformatics.
Biological pathway or process:

PI3K/AKT (other); VEGF/VEGFR (other); other pathway/process (other); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis; Bioinformatics Analysis
Clinical significance:

Circulating biomarker for BC diagnosis as part of the three-circRNA diagnostic model; no prognostic efficacy reported.
Description:

hsa_circ_0067772 is up-regulated in breast cancer patient plasma and, together with two other circRNAs, contributes to a high-performing diagnostic model. Its downstream role is only computationally inferred via predicted miRNA sponging and pathway enrichment.
Confidence score:

0.5534
Other information
Title:

Tumor-Derived circRNAs as Circulating Biomarkers for Breast Cancer.

Journal: Frontiers in pharmacology
Published: 2022
PubMed ID: 35242035
Study type:

combined biological and clinical study
Data availability: https://www.frontiersin.org/articles/10.3389/fphar.2022.811856/full#supplementary-material
Code availability: -