| Expression pattern: |
DN |
| Associated gene: |
SPRED1, PCNA, Bcl-2, Bax, Ki67 |
| Associated microRNA: |
miR-96-5p |
| Biological function: |
Circ_TEX2 functions as a tumor suppressor in hepatoma; its overexpression inhibits proliferation, migration, invasion, and xenograft tumor growth, and promotes apoptosis. |
| Molecular mechanism: |
Circ_TEX2 acts as a ceRNA by sponging miR-96-5p, thereby regulating SPRED1 expression and suppressing hepatoma progression. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Actinomycin D / DRB Stability Assay; Transfection; MTT; EdU Staining; Colony Formation Assay; Western Blot; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
Restoring circ_TEX2 production might have therapeutic value for hepatoma treatment. |
| Description: |
Circ_TEX2 is down-regulated in hepatoma tissues and cells and acts as a tumor suppressor. Mechanistically, circ_TEX2 sponges miR-96-5p to increase SPRED1 expression, thereby inhibiting hepatoma cell proliferation, migration, invasion, and xenograft tumor growth while promoting apoptosis. The study suggests that restoring circ_TEX2 may have therapeutic potential for hepatoma. |
| Confidence score: |
0.7955 |