| Expression pattern: |
DN |
| Associated gene: |
OGN, EIF4A3, SPIN1 |
| Associated microRNA: |
miR-5003-3p |
| Biological function: |
Inhibits proliferation, migration, invasion, angiogenesis, tumour growth and metastasis; reverses EMT in cervical cancer. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-5003-3p to upregulate OGN and inhibit EMT; biogenesis/expression is inhibited by EIF4A3 binding to flanking regions. |
| Biological pathway or process: |
EMT (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); angiogenesis (inhibits); metastasis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; RNase R Treatment; Actinomycin D / DRB Stability Assay; Sanger Sequencing; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; EdU Staining; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Tube Formation Assay; Western Blot; IF (Immunofluorescence); IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining |
| Clinical significance: |
circ_0087429 is negatively correlated with FIGO staging and lymphatic metastasis in cervical cancer patients. |
| Description: |
circ_0087429 is down-regulated in cervical cancer and functions as a tumour suppressor. It mainly localizes to the cytoplasm and sponges miR-5003-3p to upregulate OGN, thereby reversing EMT and inhibiting proliferation, migration/invasion, angiogenesis, and in vivo growth/metastasis. EIF4A3 binds the flanking regions and suppresses circ_0087429 biogenesis/expression. |
| Confidence score: |
0.8562 |