circRNA basic information
circBase ID: hsa_circ_0039933
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr16:68208276-68217269:+
Genomic location(hg38): chr16:68174373-68183366:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

SW620; HT-29; HCT116; 293 T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: wnt11, beta-catenin
Associated microRNA: hsa-miR-204-5p
Biological function: Promotes colorectal cancer cell proliferation, migration and invasion; inhibits apoptosis.
Molecular mechanism: Acts as a ceRNA sponge for hsa-miR-204-5p to increase wnt11 expression and activate the Wnt pathway.
Biological pathway or process:

Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
S
Validation methods:

circRNA-seq; Bioinformatics Analysis; RNase R Treatment; RT-qPCR; Sanger Sequencing; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Western Blot
Clinical significance:

-
Description:

In CRC cell lines, hsa_circ_0039933 acts as a pro-tumor circRNA by sponging hsa-miR-204-5p, thereby increasing wnt11 expression and activating Wnt/beta-catenin signaling. Knockdown suppresses proliferation, migration and invasion and increases apoptosis, while overexpression shows the opposite effects; HD-SB treatment downregulates hsa_circ_0039933 in SW620 cells.
Confidence score:

0.7198
Other information
Title:

Hedyotis diffusa-Sculellaria barbata (HD-SB) suppresses the progression of colorectal cancer cells via the hsa_circ_0039933/hsa-miR-204-5p/wnt11 axis.

Journal: Scientific reports
Published: 2023
PubMed ID: 37587207
Study type:

biological research
Data availability: GSE237129
Code availability: -