| Expression pattern: |
UP |
| Associated gene: |
MTA1, Argonaute2 (AGO2) |
| Associated microRNA: |
miR‐1296‐5p |
| Biological function: |
promotes proliferation, migration, invasion and glycolysis; suppresses apoptosis; promotes tumor growth |
| Molecular mechanism: |
ceRNA sponge mechanism: circUSPL1 sponges miR-1296-5p to upregulate MTA1 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); glycolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Sanger Sequencing; Nuclear-Cytoplasmic Fractionation; RNase R Treatment; Actinomycin D / DRB Stability Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; Colony Formation Assay; EdU Staining; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation |
| Clinical significance: |
higher circUSPL1 expression was correlated with advanced TNM stages, lymph node metastasis and tumor size |
| Description: |
circUSPL1 is up-regulated in breast cancer tissues and cell lines and mainly localizes to the cytoplasm. Functionally, circUSPL1 promotes malignant phenotypes (proliferation, migration, invasion, glycolysis) and inhibits apoptosis by acting as a ceRNA that sponges miR-1296-5p to increase MTA1, thereby supporting tumor growth in vivo. |
| Confidence score: |
0.8465 |