circRNA basic information
circBase ID: hsa_circ_0019079
Name: hsa_circ_KIF20B
Synonym: circKIF20B
Host Gene: KIF20B
Genomic location(hg19): chr10:91511102-91522592:+
Genomic location(hg38): chr10:89751345-89762835:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tissues; tumor-adjacent normal control (NC) tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: SLC31A1
Associated microRNA: -
Biological function: -
Molecular mechanism: May participate in circRNA-miRNA-mRNA co-expression regulation in CRC (network-based inference).
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

-
Description:

The study reports that hsa_circ_0019079 (circKIF20B) is up-regulated in colorectal cancer tissues versus adjacent normal tissues, supported by RNA-seq and RT-qPCR. Network analysis suggests it is part of a circRNA-miRNA-mRNA co-expression framework and may positively regulate SLC31A1, but specific miRNAs were not provided for this circRNA.
Confidence score:

0.5135
Other information
Title:

Comprehensive analysis of m6A circRNAs identified in colorectal cancer by MeRIP sequencing.

Journal: Frontiers in oncology
Published: 2022
PubMed ID: 36059637
Study type:

combined biological and clinical study
Data availability: -
Code availability: -