circRNA basic information
circBase ID: -
Name: -
Synonym: Chr7q11
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: extracellular vesicle
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum extracellular vesicles
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: 91 mRNAs
Associated microRNA: hsa-miR-3198, hsa-miR-4677-3p, hsa-miR-450b-3p, hsa-miR-944, hsa-miR-513b-5p, hsa-miR-6888-3p, hsa-miR-580-3p, hsa-miR-219a-1-3p, hsa-miR-4251, hsa-miR-4457, hsa-miR-136-3p, hsa-miR-3174, hsa-miR-616-3p
Biological function: May serve as a diagnostic biomarker for gastric cancer; positively associated with tumor progression features (tumor size, lymph node metastasis, distant metastasis, TNM stage).
Molecular mechanism: Predicted ceRNA network with miRNAs and mRNAs (circRNA-miRNA-mRNA network).
Biological pathway or process:

ceRNA regulation (other); PI3K/AKT (other); drug resistance (other); other pathway/process (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Sanger Sequencing; RNase R Treatment; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Diagnostic biomarker potential (AUC 0.749 for Chr7q11); correlated with tumor size, lymph node metastasis, and TNM stage.
Description:

Chr7q11 is an extracellular-vesicle circRNA elevated in gastric cancer patient serum EVs and is associated with more advanced clinicopathological features. It shows diagnostic value (AUC 0.749) and is included in a predicted circRNA-miRNA-mRNA (ceRNA) network.
Confidence score:

0.6556
Other information
Title:

Expression and clinical value of circRNAs in serum extracellular vesicles for gastric cancer.

Journal: Frontiers in oncology
Published: 2022
PubMed ID: 36059681
Study type:

combined biological and clinical study
Data availability: GSE165394
Code availability: -