| Expression pattern: |
UP |
| Associated gene: |
SKIL |
| Associated microRNA: |
miR-216b-5p |
| Biological function: |
Promotes proliferation, migration, invasion, EMT and glycolysis; inhibits apoptosis; promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miR-216b-5p sponge (ceRNA) to regulate SKIL expression. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); EMT (promotes); glycolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ_0029803 expression was associated with lower 5-year overall survival; circ_0029803 might be a promising molecular marker for the diagnosis of CRC. |
| Description: |
circ_0029803 is up-regulated in colorectal cancer and acts as an oncogenic circRNA. It mainly localizes to the cytoplasm and promotes CRC malignant phenotypes (proliferation, migration/invasion, EMT, glycolysis, and tumor growth) by sponging miR-216b-5p to increase SKIL expression, and high expression predicts worse overall survival. |
| Confidence score: |
0.8153 |