| Expression pattern: |
DN |
| Associated gene: |
BARX2, Wnt/beta-catenin signaling pathway |
| Associated microRNA: |
miR-942 |
| Biological function: |
inhibits proliferation; inhibits migration; inhibits invasion; represses tumor growth |
| Molecular mechanism: |
circSHPRH acts as a miR-942 sponge to upregulate BARX2 and inhibit Wnt/beta-catenin signaling |
| Biological pathway or process: |
Wnt/beta-catenin (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RNA Pull-Down; Luciferase Reporter Assay; Transfection; MTT; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
a low circSHPRH level was positively correlated with a high grade, a high pathological stage, lymphatic metastasis and an unfavorable prognosis for BCa patients |
| Description: |
circSHPRH (hsa_circ_0001649) is down-regulated in bladder cancer and acts as a tumor suppressor. It sponges miR-942 to increase BARX2 expression, thereby inhibiting Wnt/beta-catenin signaling and reducing proliferation, migration, invasion, and in vivo tumor growth. Low circSHPRH expression is associated with advanced clinicopathological features and worse survival. |
| Confidence score: |
0.8285 |